Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Competitive interaction between foreign nerves innervating frog skeletal muscle.

A D Grinnell, M S Letinsky, M B Rheuben

    The Journal of Physiology
    |April 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Monitoring transient Ca2+ dynamics with large-conductance Ca2+-dependent K+ channels at active zones in frog saccular hair cells.

    Neuroscience·2009
    Same author

    Impact of time-dependent changes in spine density and spine shape on the input-output properties of a dendritic branch: a computational study.

    Journal of neurophysiology·2004
    Same author

    Contribution of L-type Ca(2+) channels to evoked transmitter release in cultured Xenopus nerve-muscle synapses.

    The Journal of physiology·2001
    Same author

    Screening for synaptic defects revealed a locus involved in presynaptic and postsynaptic functions in Drosophila embryos.

    Journal of neurobiology·2001
    Same author

    Contribution of presynaptic calcium-activated potassium currents to transmitter release regulation in cultured Xenopus nerve-muscle synapses.

    Neuroscience·2001
    Same author

    Hypertonic enhancement of transmitter release from frog motor nerve terminals: Ca2+ independence and role of integrins.

    The Journal of physiology·2001
    Same journal

    Diving exposure and pulmonary stress.

    The Journal of physiology·2026
    Same journal

    Systems modelling of mitochondrial dynamics in different exercise regimes.

    The Journal of physiology·2026
    Same journal

    Central leptin resistance precedes obesity and drives early endocrine dysfunction.

    The Journal of physiology·2026
    Same journal

    Decoding the molecular memory of obesity using machine learning and microRNA dynamics.

    The Journal of physiology·2026
    Same journal

    Kinematic-calcium loops unravel impaired excitation-contraction coupling in MELAS-affected cardioids.

    The Journal of physiology·2026
    Same journal

    hERG1 channels and potential therapeutics for long QT syndrome.

    The Journal of physiology·2026
    See all related articles

    Foreign nerves compete for frog muscle innervation. Somatic motor nerves (s.m.n.s) show synaptic repression, while splanchnic nerves (s.p.n.s) exhibit different competition dynamics, with s.m.n.s eventually dominating.

    Area of Science:

    • Neuroscience
    • Muscle Physiology
    • Cellular Biology

    Background:

    • Nerve regeneration and reinnervation are crucial for muscle function.
    • Understanding competitive interactions between innervating nerves informs regenerative medicine.

    Purpose of the Study:

    • To investigate the competitive dynamics between two foreign somatic motor nerves (s.m.n.s) and between an s.m.n. and a preganglionic splanchnic nerve (s.p.n.) in frog skeletal muscle.
    • To elucidate the mechanisms underlying synaptic competition and reinnervation.

    Main Methods:

    • Implantation of single or paired foreign nerves (s.m.n.s or s.m.n. + s.p.n.) into denervated, transplanted frog sartorius muscles.
    • Assessment of reinnervation success via tetanic stimulation, twitch tension measurements, and intracellular recordings of end-plate potentials (e.p.p.s).

    Related Experiment Videos

    Main Results:

    • Single s.m.n.s effectively reinnervated most muscle fibers within 2-3 months.
    • Dual s.m.n. innervation led to synaptic repression, with each nerve innervating 30-50% of fibers, suggesting muscle-mediated competition.
    • s.p.n. competition with s.m.n. differed qualitatively, with s.m.n.s eventually dominating, but s.p.n.s could delay s.m.n. reinnervation.

    Conclusions:

    • Competitive interactions between innervating nerves are mediated by the muscle fiber.
    • Different nerve types (s.m.n. vs. s.p.n.) exhibit distinct competitive strategies.
    • Somatic motor nerves demonstrate a strong capacity for reinnervation and dominance over other nerve types in this model.