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Published on: August 9, 2012
Bladder dysfunction in hereditary spastic paraplegia: a clinical and urodynamic evaluation.
M Fourtassi1, S Jacquin-Courtois, M C Scheiber-Nogueira
1INSERM; UMR-S 864, Bron, France. fourtmary@yahoo.fr
Spinal Cord
|February 1, 2012
Summary
Hereditary spastic paraplegia (HSP) patients often experience voiding dysfunction, with urgency and frequency being common. Despite detrusor overactivity and dyssynergia, upper urinary tract complications are rare in HSP.
Area of Science:
- Neurology
- Urology
Background:
- Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder affecting the central nervous system.
- Patients with HSP frequently report lower urinary tract symptoms, but their etiology remains unclear.
- Urodynamic evaluations in HSP patients are infrequently documented.
Purpose of the Study:
- To characterize lower urinary tract dysfunction in a large cohort of HSP patients.
- To analyze urodynamic findings and correlate them with clinical symptoms.
Main Methods:
- Retrospective analysis of medical records from 29 HSP patients.
- Evaluation of lower urinary tract symptoms history and urodynamic parameters.
- Ultrasound examination for upper urinary tract complications.
Main Results:
- Urgency (72.4%), frequency (65.5%), and incontinence (55.2%) were prevalent symptoms.
- Central neurogenic bladder was diagnosed in 82.7% of patients.
- Detrusor overactivity (51.7%) and detrusor sphincter dyssynergia (65.5%) were common, with significant links to PVR, frequency, and nocturia.
- No upper urinary tract complications were observed via ultrasound.
Conclusions:
- HSP patients with detrusor overactivity and dyssynergia show a low risk of upper urinary tract complications, even after long-term follow-up.
- Findings can inform clinical decision-making for managing bladder dysfunction in HSP.
- This study provides valuable insights into the urodynamic profile of HSP patients.
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