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Managing long-term therapy for panic disorder.

G D Burrows1

  • 1Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.

The Journal of Clinical Psychiatry
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

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Effective panic disorder treatment combines psychotherapy and medication. Alprazolam, a benzodiazepine, demonstrated efficacy in a large study, with therapy recommended for at least six months and gradual medication tapering.

Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Diagnostic criteria for panic disorder are established.
  • Treatment strategies for panic disorder require further definition.

Purpose of the Study:

  • To evaluate the efficacy of alprazolam in treating panic disorder.
  • To provide guidance on treatment duration and medication tapering.

Main Methods:

  • A cross-national study involving approximately 1700 patients.
  • Inclusion of various pharmacotherapies including benzodiazepines, tricyclic antidepressants, and monoamine oxidase inhibitors.

Main Results:

  • Alprazolam, a triazolo analog of 1,4 benzodiazepines, proved effective.
  • The medication was associated with minimal side effects in the study population.

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Conclusions:

  • Combined psychotherapy and pharmacotherapy represent the most effective treatment for panic disorder.
  • Alprazolam therapy should extend to at least six months.
  • Medication tapering should occur over a minimum of eight weeks, particularly with higher doses.