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Updated: May 25, 2026

Myocardial Infarction and Functional Outcome Assessment in Pigs

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

Revascularization in multivessel CAD: a functional approach.

Joanne Shannon¹, Antonio Colombo

¹EMO-GVM Centro Cuore Columbus, Via Buonarotti 48, 20145 Milan, Italy.

Nature Reviews. Cardiology

|February 1, 2012

Summary

This summary is machine-generated.

Focusing on functional revascularization, guided by fractional flow reserve, improves outcomes for multivessel coronary artery disease. Tailoring treatment to individual patients and institutional expertise is crucial for optimal results.

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Area of Science:

Cardiology
Interventional Cardiology
Clinical Outcomes

Background:

Complete anatomical revascularization has been the traditional goal for multivessel coronary artery disease (CAD).
Emerging evidence suggests that reducing myocardial ischemia is more critical for improving clinical outcomes than complete anatomical restoration.
Patient outcomes are linked to addressing ischemia, reducing mortality, myocardial infarction, and angina.

Purpose of the Study:

To challenge the traditional focus on anatomical revascularization in multivessel CAD.
To advocate for a shift towards functional revascularization based on ischemia assessment.
To discuss the integration of functional assessments and patient-specific factors in revascularization decisions.

Main Methods:

Review of evidence supporting functional revascularization strategies.
Discussion of fractional flow reserve (FFR) as a key tool for ischemia assessment.
Consideration of myocardial viability, ischemic burden, clinical risk, and technical feasibility.

Main Results:

Functional assessment using fractional flow reserve provides objective evidence of ischemia.
Shifting focus from anatomical to functional revascularization may improve patient outcomes.
Personalized treatment strategies, considering individual patient factors and institutional capabilities, are essential.

Conclusions:

Contemporary treatment for multivessel CAD should prioritize functional revascularization over purely anatomical completeness.
Decisions regarding lesion revascularization must incorporate myocardial viability, ischemic burden, clinical risk, and feasibility.
Tailoring revascularization strategies to the individual patient and institutional expertise, using modern techniques and pharmacotherapy, is paramount for optimal clinical outcomes.