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Updated: May 25, 2026

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach
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Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach

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Studying a complex tumor: potential and pitfalls.

Siyuan Zheng1, Milan G Chheda, Roel G W Verhaak

  • 1Department of Bioinformatics and Computational Biology, MD Anderson Cancer Center, Houston, TX, USA.

Cancer Journal (Sudbury, Mass.)
|February 1, 2012
PubMed
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Genomic studies reveal glioblastoma multiforme alterations in genes like TP53 and EGFR. Despite insights, translating these genomic findings into novel glioblastoma multiforme therapies remains a challenge.

Area of Science:

  • Neuro-oncology
  • Genomics
  • Molecular Biology

Background:

  • Glioblastoma multiforme is a complex brain tumor with limited treatment options.
  • Genomic-based therapies show promise due to high specificity and response rates.

Purpose of the Study:

  • To review genomic studies in glioblastoma multiforme.
  • To discuss the implications of genomic research for developing new treatments.

Main Methods:

  • Analysis of DNA copy number and exon-sequencing data.
  • Identification of gene expression subtypes and their association with genomic abnormalities.

Main Results:

  • Recurrent genomic alterations identified in genes including TP53, EGFR, and IDH1.

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Last Updated: May 25, 2026

Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach
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Published on: April 25, 2025

Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy
09:17

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Published on: May 3, 2019

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  • Expression subtypes offer new insights into glioblastoma multiforme biology.

    • Conclusions:

    • Genomic research has advanced understanding of glioblastoma multiforme.
    • Translating genomic discoveries into effective clinical therapies is ongoing.