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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

[Localized scleroderma (morphea) in childhood].

L Weibel1

  • 1Abteilung für Pädiatrische Dermatologie, Kinderspital Zürich, Steinwiesstr. 75, 8032 Zürich, Schweiz. lisa.weibel@kispi.uzh.ch

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|February 1, 2012
PubMed
Summary
This summary is machine-generated.

Localized scleroderma (morphea) is a skin disease affecting deeper tissues, often starting in childhood. While it doesn't lead to systemic sclerosis, early recognition and treatment are crucial to prevent disability.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Connective Tissue Diseases

Context:

  • Localized scleroderma, or morphea, is a distinct sclerosing connective tissue disease.
  • It primarily affects the skin but can involve subcutaneous tissues, muscle, and bone.
  • Extracutaneous symptoms and antinuclear antibodies are common, yet it does not progress to systemic sclerosis.

Purpose:

  • To summarize the clinical presentation, progression, and management of localized scleroderma.
  • To highlight the diagnostic challenges and treatment delays associated with the condition.
  • To differentiate localized scleroderma from systemic sclerosis.

Summary:

  • This condition typically manifests in childhood with diverse clinical presentations, the linear variant being most common and associated with significant complications.
  • The exact cause is unknown, but genetic predisposition and potential triggers like trauma or infections are implicated.
  • Delayed diagnosis is frequent, impacting timely initiation of effective treatments.

Impact:

  • Early diagnosis and appropriate treatment, including systemic corticosteroids, methotrexate, or phototherapy, are vital to mitigate functional and cosmetic impairments.
  • Understanding the disease spectrum and potential triggers can aid in earlier recognition and management.
  • Distinguishing morphea from systemic sclerosis is critical for prognosis and treatment strategies.