Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

1.0K
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
1.0K
Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

1.9K
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
1.9K
What is a Nervous System?01:25

What is a Nervous System?

105.1K
Overview
105.1K
The Parasympathetic Nervous System01:14

The Parasympathetic Nervous System

115.8K
Overview
115.8K
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

103.9K
Overview
103.9K
Nervous System01:21

Nervous System

3.5K
The nervous system coordinates body functions through its complex network of nerve cells, enabling sensation and movement. It is divided into two primary parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and the spinal cord. The brain acts as the body's control center, processing sensory information and coordinating responses. The spinal cord functions as a major signaling pathway for the brain and the rest of the body.
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A mechanism to initiate emergency type 2 myelopoiesis.

Nature·2026
Same author

Capturing gene-cell duality in a cat's cradle.

Bioinformatics (Oxford, England)·2026
Same author

Glial Cell Line-derived Neurotrophic Factor and Retinoic Acid Synergy Unlocks Neurogenesis in Adult Myenteric Glia/Neural Progenitors.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Structural and functional gastrointestinal abnormalities in ACTA2 R179H mice modeling multisystemic smooth muscle dysfunction syndrome.

JCI insight·2026
Same author

Fat-derived neural stem cells promote nerve regeneration following peripheral nerve injury.

Stem cell research & therapy·2025
Same author

Intramuscular enteric glia persist in Hirschsprung disease and undergo neurogenesis in response to GDNF-NCAM1 signaling.

Scientific reports·2025

Related Experiment Video

Updated: Feb 7, 2026

Author Spotlight: Robust Culture of Human Enteric Neurons from Human Pluripotent Stem Cells
05:11

Author Spotlight: Robust Culture of Human Enteric Neurons from Human Pluripotent Stem Cells

Published on: May 17, 2024

2.1K

The enteric nervous system.

Valentina Sasselli1, Vassilis Pachnis, Alan J Burns

  • 1Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

Developmental Biology
|February 1, 2012
PubMed
Summary

The enteric nervous system (ENS) develops from neural crest cells (NCC) through complex molecular signaling. Understanding these pathways is crucial for treating congenital ENS diseases.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Gastroenterology

Background:

  • The enteric nervous system (ENS) controls gastrointestinal functions.
  • ENS development relies on neural crest cell (NCC) migration, proliferation, and differentiation.
  • Congenital ENS diseases arise from developmental defects.

Purpose of the Study:

  • To review molecular mechanisms governing ENS development.
  • To highlight key molecules influencing NCC behavior and neuronal differentiation.
  • To bridge animal study findings to clinical applications for ENS disorders.

Main Methods:

  • Review of molecular pathways regulating NCC development.
  • Analysis of signaling pathways (e.g., Ret/Gdnf, EdnrB/Et-3).
  • Examination of transcription factors (e.g., Sox10, Phox2b) and morphogens.

More Related Videos

In Situ Ca2+ Imaging of the Enteric Nervous System
11:26

In Situ Ca2+ Imaging of the Enteric Nervous System

Published on: January 29, 2015

18.0K
Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System
11:53

Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System

Published on: October 26, 2010

17.7K

Related Experiment Videos

Last Updated: Feb 7, 2026

Author Spotlight: Robust Culture of Human Enteric Neurons from Human Pluripotent Stem Cells
05:11

Author Spotlight: Robust Culture of Human Enteric Neurons from Human Pluripotent Stem Cells

Published on: May 17, 2024

2.1K
In Situ Ca2+ Imaging of the Enteric Nervous System
11:26

In Situ Ca2+ Imaging of the Enteric Nervous System

Published on: January 29, 2015

18.0K
Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System
11:53

Oral Administration of Rotenone using a Gavage and Image Analysis of Alpha-synuclein Inclusions in the Enteric Nervous System

Published on: October 26, 2010

17.7K

Main Results:

  • Identified key molecular players in NCC proliferation, survival, and migration.
  • Detailed signaling pathways (Ret, EdnrB, Semaphorin 3A) and their roles.
  • Summarized factors influencing neuronal subtype specification and morphology.

Conclusions:

  • Molecular mechanisms of ENS development are complex and involve multiple pathways.
  • Further research is needed to translate findings into treatments for congenital ENS diseases.
  • Understanding ENS development is vital for addressing gastrointestinal motility disorders.