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Photodynamic effect in near-IR light by a photocytotoxic iron(III) cellular imaging agent
Uttara Basu1, Imran Khan, Akhtar Hussain
1Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, Karnataka, India.
Angewandte Chemie (International Ed. in English)
|February 1, 2012
Abstract:
A red light for cancer cells: an iron(III) complex (1, see picture) that contains an anthracenyl fluorophore moiety and a catecholate ligand is a potent, metal-based PDT agent that efficiently photocleaves DNA in near-infrared light, has significant nuclear uptake, and high photocytotoxicity in red light by an apoptotic pathway in HeLa and MCF-7 cancer cells.
