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Related Concept Videos

Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...

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Related Experiment Video

Updated: May 25, 2026

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
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Off-pump transapical mitral valve replacement: evaluation after one month.

Kenji Iino1, Jessica Boldt, Lucian Lozonschi

  • 1Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|February 1, 2012
PubMed
Summary

This study shows a novel mitral valved stent was successfully implanted in pigs, demonstrating good valve function and stability for up to 8 weeks. The device showed adequate deployment and anchorage with minimal regurgitation.

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Area of Science:

  • Cardiovascular research
  • Biomedical engineering
  • Surgical innovation

Background:

  • Mitral valve disease requires innovative treatment options.
  • Transcatheter valve replacement is a growing field.
  • A novel valved stent was developed for mitral valve implantation.

Purpose of the Study:

  • To evaluate the outcomes of a novel mitral valved stent in a porcine model.
  • To assess the deployment, function, and hemodynamic stability of the stent.
  • To investigate the short-term performance of the device.

Main Methods:

  • A custom nitinol stent with a bovine pericardial valve was designed.
  • Transapical implantation was performed in six pigs.
  • Hemodynamic stability and valve function were assessed using TEE, ventriculography, and CT.

Main Results:

  • Successful deployment and positioning were achieved in most animals.
  • Minimal paravalvular leakage and small gradients were observed.
  • Normal hemodynamics and stability were maintained post-implantation, with tissue ingrowth observed.

Conclusions:

  • The novel mitral valved stent demonstrated adequate deployment and anchorage.
  • Good valve function was observed in pigs up to 8 weeks post-implantation.
  • The device shows promise for treating mitral valve disease.