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IMP-29, a novel IMP-type metallo-β-lactamase in Pseudomonas aeruginosa

Katy Jeannot1, Laurent Poirel, Marjorie Robert-Nicoud

  • 1Centre National de la Résistance aux Antibiotiques, Laboratoire associé Pseudomonas aeruginosa, Hôpital Jean Minjoz, Besançon, France.

Antimicrobial Agents and Chemotherapy
|February 1, 2012
PubMed

Insights

Researchers discovered a new metallo-beta-lactamase, IMP-29, in multidrug-resistant Pseudomonas aeruginosa. This enzyme efficiently breaks down carbapenems, a critical class of antibiotics, raising concerns for antimicrobial resistance.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Biochemistry

Background:

  • Multidrug resistance in Pseudomonas aeruginosa poses a significant global health threat.
  • Metallo-beta-lactamases (MBLs) are a class of enzymes conferring resistance to carbapenems, a last-resort antibiotic class.
  • Emergence of novel MBL variants necessitates continuous surveillance and characterization.

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