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Updated: May 25, 2026

An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium
12:18

An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium

Published on: July 22, 2011

First human isolate of Salmonella enterica serotype Enteritidis harboring blaCTX-M-14 in South America

Inés Bado1, Virginia García-Fulgueiras, Nicolás F Cordeiro

  • 1Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

Antimicrobial Agents and Chemotherapy
|February 1, 2012
PubMed

Insights

A clinical Salmonella Enteritidis strain resistant to oxyiminocephalosporins carried the bla(CTX-M-14) gene on a conjugative plasmid. This marks the first detection of this resistance gene in human Salmonella Enteritidis in South America.

Area of Science:

  • Microbiology
  • Genetics
  • Antimicrobial Resistance

Background:

  • Oxyiminocephalosporins are critical antibiotics for treating bacterial infections.
  • Salmonella Enteritidis is a significant foodborne pathogen.
  • Emergence of antibiotic resistance in bacteria poses a global health threat.

Observation:

  • A clinical isolate of Salmonella Enteritidis exhibited resistance to oxyiminocephalosporins.
  • Molecular analysis identified the bla(CTX-M-14) gene conferring this resistance.
  • The gene was located on a 95-kb IncI1 conjugative plasmid, maintained by a pndAC addiction system.

Findings:

  • The Salmonella Enteritidis strain belonged to sequence type 11 (ST11).
  • The bla(CTX-M-14) gene was linked to IS903 on the IncI1 plasmid.
  • This represents the first report of bla(CTX-M-14) in human-derived Salmonella Enteritidis in South America.

Implications:

  • This finding highlights the potential for horizontal gene transfer of antibiotic resistance genes.
  • It underscores the need for enhanced surveillance of antimicrobial resistance in South America.
  • Understanding plasmid-mediated resistance mechanisms is crucial for developing effective treatment strategies.

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