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Related Concept Videos

Instinctive Drift01:05

Instinctive Drift

Instinctive drift refers to the tendency of animals to revert to their innate behaviors despite repeated reinforcement. Breland and Breland demonstrated this concept in an experiment with a raccoon. The raccoon was trained to pick up two coins and place them in a container in exchange for food. Initially, the raccoon learned to associate the coins with food, making them a conditioned stimulus or a substitute for food. However, over time, the raccoon became less willing to put the coins into the...

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Related Experiment Video

Updated: May 25, 2026

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
08:07

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Published on: August 24, 2016

D-1 receptor involvement in reward-related learning.

R J Beninger1

  • 1Department of Psychology, Queen's University, Kingston, Canada K7L 3N6.

Journal of Psychopharmacology (Oxford, England)
|February 1, 2012
PubMed
Summary

Dopamine D-1 and D-2 receptors play crucial roles in reward learning. D-2 agonists and amphetamine enhanced conditioned reward, while D-1 agonists impaired it, suggesting D-1 receptors are critical for learning associated with rewarding stimuli.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Dopamine (DA) signaling is integral to reward processing and learning.
  • Understanding the specific roles of dopamine receptor subtypes (D-1 and D-2) is crucial for elucidating these mechanisms.

Purpose of the Study:

  • To investigate the involvement of dopamine D-1 and D-2 receptors in reward-related learning using various behavioral paradigms.
  • To compare the effects of dopamine, amphetamine, and subtype-specific agonists and antagonists on conditioned reward, self-administration, and place conditioning.

Main Methods:

  • Utilized conditioned reward, self-administration, and place conditioning paradigms in animal models.
  • Administered apomorphine, amphetamine, D-1 agonist (SKF 38393), D-2 agonists (bromocriptine, quinpirole), and D-1 antagonists (SCH 23390, SCH 39166).

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Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
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Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

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Related Experiment Videos

Last Updated: May 25, 2026

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
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Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

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Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology

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Main Results:

  • D-2 agonists and amphetamine enhanced conditioned reward responding, were self-administered, and produced place preferences.
  • Apomorphine impaired conditioned reward but was self-administered and produced place preference.
  • The D-1 agonist SKF 38393 impaired conditioned reward, did not support self-administration, but produced place preference.
  • D-1 antagonists blocked the effects of reward in these paradigms.

Conclusions:

  • Dopamine D-2 receptors are involved in mediating the reinforcing effects of drugs and conditioned stimuli.
  • Dopamine D-1 receptors appear critically involved in reward-related learning, potentially by modulating the association between stimuli and reward.
  • The distinct effects of D-1 and D-2 agonists highlight their differential roles in reward processing and learning.