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Reduction of dyskinesias and psychiatric disability with clozapine over different time courses
N C Moore1, P A Lewitt, S Gershon
1Mercer University School of Medicine, 1550 College Street, Macon, GA 31207.
Abstract:
Nine subjects with schizophrenia or schizoaffective disorder were treated with clozapine, 500 mg/day for at least 3 months. Each was affected by tardive dyskinesia whose severity was reduced significantly after 3 months of treatment but not at earlier monthly assessments. In contrast, psychiatric symptoms were lessened significantly after 1 month. The more delayed improvement of dyskinesia as compared to the pace of psychiatric improvement suggests a differential effect of the drug.
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