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Related Concept Videos

Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Sensory Perception: Organization of the Somatosensory System01:11

Sensory Perception: Organization of the Somatosensory System

The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the stimulus...
Overview of Somatic Sensory Pathways01:29

Overview of Somatic Sensory Pathways

Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the posterior columns...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at the...

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Related Experiment Video

Updated: May 25, 2026

Structured Motor Rehabilitation After Selective Nerve Transfers
09:34

Structured Motor Rehabilitation After Selective Nerve Transfers

Published on: August 15, 2019

Somatosensory scaffolding structures.

Nathaniel A Jeske1

  • 1Departments of Oral and Maxillofacial Surgery, Pharmacology, University of Texas Health Science Center at San Antonio TX, USA.

Frontiers in Molecular Neuroscience
|February 1, 2012
PubMed
Summary
This summary is machine-generated.

Somatosensory perception dynamically changes due to signaling events. Scaffolding structures regulate neuronal excitability, impacting responses to thermal, mechanical, and chemical stimuli.

Keywords:
AKAPJeskeafferenthomerlipid raftpainscaffold

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Area of Science:

  • Neuroscience
  • Sensory Biology
  • Molecular Signaling

Background:

  • Somatosensory perception involves dynamic signaling events.
  • Receptor activity is altered by over-activation (desensitization) or tissue injury (sensitization).
  • These changes affect responses to thermal, mechanical, and chemical stimuli.

Purpose of the Study:

  • To investigate scaffolding structures that regulate somatosensory neuronal excitability.
  • To understand how these structures modulate sensory receptor activity.
  • To explore the impact of altered receptor activity on organismal responses.

Main Methods:

  • Focus on scaffolding proteins involved in somatosensory pathways.
  • Analysis of signaling mechanisms controlling receptor activity.
  • Examination of neuronal excitability regulation.

Main Results:

  • Scaffolding structures play a critical role in modulating somatosensory neuronal excitability.
  • Dynamic alterations in receptor activity impact sensory perception.
  • These mechanisms are crucial for both homeostasis and damage detection.

Conclusions:

  • Scaffolding structures are key regulators of somatosensory neuronal function.
  • Understanding these mechanisms is vital for comprehending sensory processing and its dysregulation.
  • Targeting these structures may offer therapeutic potential for sensory disorders.