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Updated: May 25, 2026

Evaluating Autophagy Levels in Two Different Pancreatic Cell Models Using LC3 Immunofluorescence
Published on: April 28, 2023
Autophagy in pancreatic cancer
Daniel Grasso1, Maria Noé Garcia, Juan L Iovanna
1Parc Scientifique et Technologique de Luminy, Stress Cellulaire, INSERM U624, 163 avenue de Luminy, CP 915, 13288 Marseille Cedex 9, France.
Abstract:
Pancreatic adenocarcinoma (PDAC) is a devastating disease with an extremely poor life expectancy and no effective treatment. Autophagy is a process of degradation of cytoplasmic component capable of recycling cellular components or eliminate specific targets. The presence of autophagy in PDAC has been demonstrated. However, the implicated cellular pathways are not fully understood and, more importantly, the role of autophagy in PDAC is matter of intensive debate. This review summarizes recently published data in an attempt to clarify the importance of autophagy in this disease and try to reconcile apparently contradictory results.
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