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Evaluation of Helicobacter pylori infection in patients with common migraine headache

Morteza Hosseinzadeh1, Afra Khosravi, Kourosh Saki

  • 1Department of Immunology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

Archives of Medical Science : AMS
|February 1, 2012
PubMed
Abstract

Insights

Helicobacter pylori infection is linked to migraine headaches. Treating H. pylori may significantly reduce migraine severity and frequency.

Area of Science:

  • Medical Science
  • Infectious Diseases
  • Neurology

Background:

  • Migraine affects 12-15% of the global population, causing significant headache burden.
  • Emerging research explores the connection between infectious agents, like Helicobacter pylori, and migraine prevalence.
  • This study investigates the role of H. pylori infection in migraine patients.

Purpose of the Study:

  • To evaluate the presence of immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies to H. pylori in individuals suffering from migraine headaches.
  • To compare H. pylori antibody levels between migraine patients and a healthy control group.
  • To explore potential correlations between H. pylori infection and migraine characteristics.

Main Methods:

  • A case-control study comparing migraine patients with healthy individuals.
  • Analysis included diagnostic criteria for migraine, H. pylori IgG and IgM antibody levels (mean optical density), and various demographic and clinical factors.
  • Factors assessed included age, occupation, gastrointestinal disorders, migraine history, diet, medications, sleep disorders, stress, and environmental influences.

Main Results:

  • A significant difference in mean optical density (OD) values for both H. pylori IgG and IgM antibodies was observed between migraine patients and controls.
  • Elevated IgG and IgM antibody levels to H. pylori were found in the migraine group compared to the control group.
  • Gastrointestinal disorders were prevalent in 75.6% of migraine patients, with gastric reflux being the most common sign.

Conclusions:

  • Active H. pylori infection shows a strong association with the occurrence and severity of migraine headaches.
  • Treatment and eradication of H. pylori infection demonstrated a significant reduction in migraine symptoms.
  • Eradicating H. pylori infection holds promise for potentially curing or substantially alleviating migraine headaches.
Keywords:
Helicobacter pyloriantibody titreheadachemigraine

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