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Related Experiment Video

Updated: May 25, 2026

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

Published on: January 31, 2020

[Immune reconstitution inflammatory syndrome].

Guillaume Breton¹

¹Médecine interne 1, Hôpital de la Pitié-Salpêtrière, 47-83 bid de l'hôpital, 75013 Paris. guillaume.breton@psl.aphp.fr

Bulletin De L'Academie Nationale De Medecine

|February 2, 2012

Summary

This summary is machine-generated.

Immune Reconstitution Inflammatory Syndrome (IRIS) involves severe immune responses in HIV patients starting antiretroviral therapy. Diagnosis and treatment strategies for IRIS remain challenging, impacting patient outcomes.

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Last Updated: May 25, 2026

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

Published on: January 31, 2020

Area of Science:

Immunology
Infectious Diseases
HIV/AIDS Research

Context:

Immune Reconstitution Inflammatory Syndrome (IRIS) is a complex condition affecting chronically HIV-infected individuals.
IRIS arises from an overactive immune response following the initiation of antiretroviral therapy (ART).
Pathogens like mycobacteria and fungi are common triggers, alongside other infections and inflammatory conditions.

Purpose:

To describe the heterogeneous pathological manifestations of IRIS.
To highlight the diagnostic challenges and undetermined optimal therapeutic strategies for IRIS.
To review the common causes and general outcomes of IRIS.

Summary:

IRIS presents as a spectrum of inflammatory conditions due to dysregulated immunity post-ART initiation in HIV patients.
Mycobacteria and fungi are primary culprits, but diverse pathogens and autoimmune disorders can also trigger IRIS.
While often favorable, outcomes can be severe, particularly with central nervous system involvement, underscoring the need for better diagnostic and treatment protocols.

Impact:

Improved understanding of IRIS pathogenesis and clinical presentation.
Highlights the need for refined diagnostic criteria and therapeutic guidelines for IRIS management.
Informs clinical practice regarding patient monitoring and intervention strategies for IRIS in HIV-infected populations.