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Updated: May 25, 2026

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice
Published on: January 31, 2020
[Immune reconstitution inflammatory syndrome]
1Médecine interne 1, Hôpital de la Pitié-Salpêtrière, 47-83 bid de l'hôpital, 75013 Paris. guillaume.breton@psl.aphp.fr
Abstract:
The immune reconstitution inflammatory syndrome (IRIS), occurring in chronically HIV-infected patients, is a set of heterogeneous pathological manifestations attributed to an excessive and deregulated immune response to various pathogens and non infectious stimuli shortly after initiation of antiretroviral therapy. Mycobacteria and fungi are the main causes of IRIS, but many other pathogens and autoimmune/inflammatory disorders have also been incriminated Diagnosis is difficult and the optimal therapeutic strategy remains to be determined. Steroids have been recommended for tuberculosis-associated IRIS. Outcome is generally favorable, with the exception of central nervous system involvement.
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