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Related Experiment Video

Updated: May 25, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

[Optical biopsy: the surgical perspective].

Michel Canis1, Benoît Rabischong, Revaz Botchorishvili

  • 1Chirurgie gynécologique, CHU Estaing, 1, place Lucie Aubrac, 63003 Clermont-Ferrand Cedex 1. mcanis@chu-clermontferrand.fr

Bulletin De L'Academie Nationale De Medecine
|February 2, 2012
PubMed
Summary

Optical biopsy techniques offer real-time histologic images and image-guided surgery. Their diagnostic value and reproducibility require further study, but they promise advancements in patient diagnosis and treatment evaluation.

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Area of Science:

  • Medical Imaging
  • Surgical Technology
  • Pathology

Context:

  • Over the past two decades, numerous intraoperative imaging techniques, collectively termed 'optical biopsy,' have emerged.
  • Optical biopsy encompasses two primary approaches: endomicroscopy for in-situ histologic imaging and image-guided surgery (e.g., fluorescence, sentinel node biopsy, enhanced reality).

Purpose:

  • To review the advancements and potential applications of optical biopsy techniques in surgical settings.
  • To discuss the challenges and future directions for intraoperative histology and image-guided surgery.

Summary:

  • Intraoperative optical biopsy techniques provide surgeons with real-time histologic images and enhanced surgical navigation.
  • Key challenges include determining the diagnostic value, ensuring reproducibility outside expert centers, and defining the roles of surgeons and pathologists in image interpretation.

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Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
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Published on: October 21, 2022

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Last Updated: May 25, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

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Published on: August 9, 2024

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
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Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

  • The integration of image-guided surgery and endomicroscopy is anticipated to significantly advance in-situ tissue examination for diagnosis and treatment assessment.

    • Impact:

    • Optical biopsy techniques have the potential to revolutionize intraoperative diagnostics, offering immediate tissue analysis.
    • Successful implementation could reduce the need for conventional biopsies and improve treatment evaluation accuracy.
    • The future of surgical diagnostics likely involves a synergistic combination of advanced imaging and real-time histologic analysis.