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The interplay between inflammation and oxidative stress in carcinogenesis
S Nowsheen1, K Aziz, T B Kryston
1Department of Radiation Oncology, Hazelrig-Salter Radiation Oncology Center, University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL 35294, USA.
Current Molecular Medicine
|February 2, 2012
Summary
Targeting the tumor microenvironment, including stroma, is key for cancer prevention and therapy. Understanding its role in inflammation and oxidative stress can reveal new treatment targets for cancer and metastasis.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Emerging data highlight the tumor microenvironment's (TME) critical role in carcinogenesis.
- The stroma is an integral component of the TME, inseparable from tumor cells.
- Dysfunction in the TME is increasingly recognized as fundamental to cancer development.
Purpose of the Study:
- To review the key aspects of carcinogenesis focusing on the TME.
- To elucidate the roles of oxidative stress and inflammation in cancer.
- To explore the connection between metastasis, oxidative stress, and the TME.
Main Methods:
- Literature review of recent findings on the TME.
- Analysis of the interplay between inflammation, oxidative stress, and DNA damage.
- Examination of the TME's key players contributing to cancer progression.
Main Results:
- Oxidative stress and inflammation are significant contributors to carcinogenesis.
- The TME harbors key players driving inflammation, oxidative stress, and DNA damage.
- A strong link exists between metastasis and oxidative stress within the TME.
Conclusions:
- Targeting the TME offers promising avenues for cancer chemoprevention and therapy.
- Understanding the TME is crucial for developing novel treatment strategies.
- The TME's role in inflammation and oxidative stress has implications for cancer prognosis and treatment.
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