Related Experiment Video
Updated: May 25, 2026

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
The tumor suppressor gene ARF as a sensor of oxidative stress
M Liontos1, I S Pateras, K Evangelou
1Molecular Carcinogenesis Group, Laboratory of Histology-Embryology, Medical School, University of Athens, 75 Mikras Asias Str, Goudi, GR-11527, Athens, Greece.
Abstract:
Oxidative stress as a result of either exogenous stimuli or cellular metabolism affects several cellular processes such as proliferation, apoptosis, cell death and senescence. Consequently, it is implicated in the pathogenesis of various human diseases like cancer, diabetes mellitus, atherosclerosis, neurodegenerative diseases and aging. Oxidative stress is implicated in carcinogenesis either by directly provoking DNA damage or through the regulation of intracellular signaling cascades. In both cases the cellular response to oxidative stress is determined by the cellular context. ARF, the alternative protein product of the CDKN2A locus has been recently recognized as a novel sensor of oxidative stress, in a β-catenin and Hsp70-mediated manner. Since, improved understanding of cellular responses to oxidative stress may facilitate the design of novel antineoplastic regimens, we herein review the mechanisms by which oxidative stress promotes carcinogenesis, focusing on the role of ARF as a sensor of oxidative stress.
Related Concept Videos
Abnormal Proliferation
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
DNA Damage can Stall the Cell Cycle
DNA Damage Can Stall the Cell Cycle
The Ras Gene
Ras is a superfamily...
PI3K/mTOR/AKT Signaling Pathway
