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Related Concept Videos

Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: May 25, 2026

Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay
11:38

Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay

Published on: September 14, 2021

FGF/FGFR signaling in bone formation: progress and perspectives.

Pierre J Marie1, Hichem Miraoui, Nicolas Sévère

  • 1Laboratory of Osteoblast Biology and Pathology, INSERM UMR-606 and University Paris Diderot, Paris F-75475, France. pierre.marie@inserm.fr

Growth Factors (Chur, Switzerland)
|February 2, 2012
PubMed
Summary

Fibroblast growth factors (FGFs) and their receptors (FGFRs) are key regulators of bone formation. Recent research clarifies FGF/FGFR signaling, its interactions, and degradation mechanisms in osteoblastogenesis, offering therapeutic potential for bone disorders.

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Last Updated: May 25, 2026

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Developmental Biology

Background:

  • Fibroblast growth factors (FGFs) are crucial signaling molecules regulating bone formation.
  • FGFs exert their effects by activating FGF receptors (FGFRs) and downstream pathways.
  • Osteoblast lineage cells are key targets of FGF/FGFR signaling in bone development.

Purpose of the Study:

  • To review recent advances in understanding FGF/FGFR signaling in osteogenesis.
  • To highlight novel insights from mouse and human models.
  • To explore the role of molecular targets and pathway crosstalks in osteoblastogenesis.

Main Methods:

  • Review of recent scientific literature on FGF/FGFR signaling.
  • Analysis of genomic studies implicating FGF/FGFR targets.
  • Examination of studies on FGF/FGFR pathway crosstalks and receptor degradation.

Main Results:

  • Identification of specific FGF/FGFR pathways controlling osteogenesis.
  • Genomic data confirms the role of FGF/FGFR targets in osteoblastogenesis.
  • Crosstalks with other signaling pathways and FGFR degradation mechanisms are critical regulators.

Conclusions:

  • Recent discoveries elucidate FGF/FGFR signaling mechanisms in osteoblastogenesis.
  • Understanding these pathways offers potential therapeutic strategies for skeletal disorders.
  • Targeting FGF/FGFR signaling may be beneficial for conditions with abnormal bone formation.