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Updated: May 25, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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The CDK9 C-helix exhibits conformational plasticity that may explain the selectivity of CAN508

Sonja Baumli1, Alison J Hole, Martin E M Noble

  • 1Northern Institute for Cancer Research, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K. sonja.baumli@ncl.ac.uk

ACS Chemical Biology
|February 2, 2012
PubMed

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