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Related Experiment Video

Updated: May 25, 2026

Rapid, Safe, and Simple Manual Bedside Nucleic Acid Extraction for the Detection of Virus in Whole Blood Samples
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Published on: June 30, 2018

Rickets in Denmark.

Signe Sparre Beck-Nielsen1

  • 1Department of Pediatrics, Hospital of Southwest Denmark, Finsensgade 35, 6700 Esbjerg, Denmark. sbeck-nielsen@health.sdu.dk

Danish Medical Journal
|February 2, 2012
PubMed
Summary

Nutritional rickets, caused by vitamin D or calcium deficiency, is re-emerging in industrialized nations. This study investigates the unknown incidence of nutritional and hereditary rickets, including hypophosphatemic rickets, in Scandinavia.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Genetics

Background:

  • Rickets, a bone mineralization defect in children, has forms including nutritional and hereditary. While nutritional rickets declined due to vitamin D supplementation, it is now reappearing.
  • Hereditary rickets, particularly hypophosphatemic rickets (HR), is believed to be the leading cause in industrialized countries, yet its prevalence in Scandinavia is uncharacterized.
  • The presentation of hereditary rickets in adult patients and potential gender-based differences in disease severity require further investigation.

Purpose of the Study:

  • To determine the incidence and prevalence of nutritional and hereditary rickets in Scandinavia.
  • To characterize the genotype and phenotype of Scandinavian patients with hypophosphatemic rickets (HR).
  • To describe the disease course in adult patients and explore gender differences in rickets severity.

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Main Methods:

  • Epidemiological analysis of rickets incidence and prevalence in Scandinavian populations.
  • Genetic and clinical phenotyping of patients diagnosed with hypophosphatemic rickets (HR).
  • Retrospective review of adult patient data to assess long-term disease characteristics and treatment outcomes.

Main Results:

  • Data on the incidence and prevalence of nutritional and hereditary rickets in Scandinavia are currently unknown.
  • Genotype and phenotype data for Scandinavian hypophosphatemic rickets (HR) patients have not been previously characterized.
  • Limited information exists on adult rickets presentation, treatment efficacy, and gender-specific severity.

Conclusions:

  • The epidemiology of rickets in Scandinavia, encompassing both nutritional and hereditary forms, remains largely uninvestigated.
  • Characterization of Scandinavian hypophosphatemic rickets (HR) patients is needed to understand genetic and phenotypic variations.
  • Further research is essential to elucidate the adult disease spectrum, treatment effectiveness, and gender disparities in rickets severity.