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Updated: May 25, 2026
A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure
Published on: October 24, 2018
DNA microarray analysis of transcriptional responses of rats housed on solid and grid cage flooring
Masayuki Uehara1, Ayako Nishio, Satoshi Inoue
1Division of Laboratory Animal Research, Research Center for Human and Environmental Sciences, Shinshu University, 3-1-1 Asahi, Matsumoto 390-8621, Japan. Uehara.Masayuki@exc.epson.co.jp
Abstract:
We performed DNA microarray analysis on the white blood cells (WBCs) of rats housed on solid and grid cage flooring. The expression levels of 50 genes were found to increase more than 2-fold in the WBCs on grid cage flooring, including many genes encoding proteins involved in inflammatory or immune responses. It is therefore suggested that the health and welfare of laboratory rats is likely to be improved by housing rats on solid floors.
