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Updated: May 25, 2026

A Novel In Vitro Model of Blast Traumatic Brain Injury
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Published on: December 21, 2018

Do hyperbaric oxygen-induced seizures cause brain damage?

Liran Domachevsky1, Chaim G Pick, Yehuda Arieli

  • 1Israel Naval Medical Institute, IDF Medical Corps, Haifa, Israel. liranura@gmail.com

Epilepsy Research
|February 2, 2012
PubMed
Summary
This summary is machine-generated.

Hyperbaric oxygen-induced seizures may cause cell damage, activating apoptosis in the mouse hippocampus. This study challenges the notion that these seizures are harmless, revealing potential cellular harm.

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Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice
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Published on: June 11, 2020

Area of Science:

  • Neuroscience
  • Cell Biology
  • Toxicology

Background:

  • Central nervous system oxygen toxicity, a risk of hyperbaric oxygen therapy, can cause seizures.
  • The prevailing view is that hyperbaric oxygen-induced seizures are benign and cause no lasting harm.

Purpose of the Study:

  • To investigate the cellular damage, specifically apoptosis, in the mouse brain following hyperbaric oxygen-induced seizures.
  • To challenge the long-held assumption that these seizures are harmless.

Main Methods:

  • Mice were exposed to hyperbaric oxygen (6 atmospheres absolute) and seizures were induced.
  • Apoptotic markers (caspase 9, caspase 3, cytochrome c) were measured in the cortex and hippocampus at 1 hour and 7 days post-seizure.
  • Levels were compared between seizure-exposed groups and non-exposed control groups.

Main Results:

  • Significant increases in caspase 3, cytochrome c, and caspase 9 were observed in the hippocampus 7 days after seizures.
  • In the cortex, altered levels of caspase 9 fragments were noted 1 hour after seizures, with higher levels in controls.

Conclusions:

  • Hyperbaric oxygen-induced seizures activate apoptotic pathways in the mouse hippocampus.
  • The observed changes in the cortex require further investigation to understand their mechanisms and implications.
  • These findings suggest that hyperbaric oxygen-induced seizures may not be as harmless as previously assumed.