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[Development of bioanalytical techniques using micro- and nanostructures for medical applications]
1Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Nagoya, Japan. kaji.noritada@g.mbox.nagoya-u.ac.jp
Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|February 2, 2012
Summary
Micro- and nanobiodevices enable precise single-molecule analysis and separation. These innovations advance medical diagnostics and regenerative medicine from basic research to clinical applications.
Area of Science:
- Biotechnology and Biomedical Engineering
- Nanotechnology
- Analytical Chemistry
Context:
- Micro- and nanobiodevices leverage micro/nanospace for biomolecule analysis.
- Current research focuses on accelerating medical diagnosis and regenerative medicine.
- Novel analytical techniques are being developed to overcome past limitations.
Purpose:
- To develop and demonstrate unique analytical techniques using precisely defined nanospaces.
- To understand nanofluidics within nanopillar and nanowall array structures.
- To explore the transfer of micro- and nanodevices to clinical practices.
Summary:
- Developed nanopillar and nanowall array structures for single-molecule measurement and separation.
- Investigated nanofluidics using physicochemical and biological approaches.
- Demonstrated unique analytical techniques specific to nanospaces.
Impact:
- Accelerating innovation from basic research to clinical diagnosis and therapy.
- Enabling high-speed, high-sensitivity detection of cancer and disease markers.
- Facilitating clinical applications such as blood plasma separation and therapeutic drug monitoring.
