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Increased serum bilirubin level is related to good collateral development in patients with chronic total coronary

Turan Erdogan1, Yüksel Ciçek, Sinan Altan Kocaman

  • 1Department of Cardiology, Rize University Medical Faculty, Turkey.

Internal Medicine (Tokyo, Japan)
|February 2, 2012
PubMed

Insights

Higher serum bilirubin levels are linked to better coronary collateral growth in patients with chronic total coronary occlusion (CTO). Bilirubin

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Bilirubin, a bile pigment, possesses antioxidant properties.
  • Previous studies suggest a negative association between bilirubin and coronary artery disease (CAD).
  • The role of physiological serum bilirubin levels (SBLs) in coronary collateral development in chronic total coronary occlusion (CTO) remains unclear.

Purpose of the Study:

  • To investigate the association between SBLs and coronary collateral development in patients with CTO.
  • To determine if higher SBLs within physiological ranges are associated with improved collateral growth.

Main Methods:

  • Retrospective analysis of coronary angiograms from 179 patients with suspected CAD and at least one CTO.
  • Classification of collateral development as good (110 patients) or poor (69 patients) using the Cohen-Rentrop method.
  • Multivariate analysis to identify factors associated with coronary collateral development.

Main Results:

  • Patients with good collateral development exhibited higher SBLs (p<0.001) and lower fasting plasma glucose (FPG) (p=0.024) compared to those with poor collateral development.
  • Higher SBLs (OR for per 0.1-mg/dL increase: 1.832, p<0.001) and a greater number of CTO vessels (OR: 5.642, p=0.007) were positively associated with coronary collateral development.
  • FPG was negatively associated with collateral development (OR: 0.981, p=0.003).

Conclusions:

  • Higher SBLs within physiological ranges are associated with favorable coronary collateral growth in patients with CTO.
  • SBL may play a role in differential coronary collateral vessel development in patients with CAD.
  • The anti-inflammatory and antioxidant properties of bilirubin likely mediate this effect.
Abstract

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