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Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

[Virusenteritis in childhood (author's transl)]

O H Braun

    Klinische Padiatrie
    |May 1, 1979
    PubMed

    Insights

    Viral infections cause most non-bacterial infantile enteritis. Rotavirus is a widespread cause of gastroenteritis in children globally, alongside other viruses like enteroviruses and adenoviruses.

    Area of Science:

    • Virology
    • Pediatrics
    • Gastroenterology

    Context:

    • Bacterial infections account for approximately 20% of infantile enteritis cases.
    • The majority of non-bacterial infantile enteritis cases are presumed to be viral in origin.
    • Research into enterotropic viruses causing infantile gastroenteritis began in 1943, with significant advancements since the mid-1950s.

    Purpose:

    • To review the known viral agents responsible for infantile enteritis and gastroenteritis.
    • To highlight the historical discovery and evolving understanding of enteroviruses, adenoviruses, and other viral pathogens.
    • To emphasize the significant role of Rotavirus as a primary cause of acute infantile gastroenteritis worldwide.

    Summary:

    • Enteroviruses and adenoviruses have been identified as causative agents of infantile gastroenteritis.
    • The Norwalk agent, discovered in 1973, primarily affects adults but underscores the diversity of enteritis-causing viruses.
    • Rotavirus has emerged as the most prevalent cause of acute infantile gastroenteritis globally, implicated in 40-60% of cases.
    • More recently, Coronaviruses and Astroviruses have been detected as potential causes of gastroenteritis in animals and humans.

    Impact:

    • Establishes Rotavirus as a major global pathogen in pediatric gastroenteritis.
    • Provides a historical overview of viral enteritis research, identifying key discoveries.
    • Suggests ongoing research into emerging viral agents like Coronaviruses and Astroviruses in human and animal health.

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