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Eccrine poromatosis associated with polychemotherapy
Kazuyasu Fujii1, Seiko Aochi, Chinatsu Takeshima
1Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Acta Dermato-Venereologica
|February 2, 2012
Summary
Multiple eccrine poromas (eccrine poromatosis) can develop after intensive chemotherapy, even years later. This finding suggests chemotherapy, like radiotherapy, may contribute to eccrine poromatosis development.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Eccrine poroma is typically a solitary tumor.
- Multiple eccrine poromas (eccrine poromatosis) are rare.
- Previous reports linked eccrine poromatosis to radiotherapy and polychemotherapy.
Observation:
- This study presents four cases of multiple eccrine poromas.
- Patients had undergone or were undergoing intensive chemotherapy for non-Hodgkin's lymphoma or malignant fibrous histiocytosis.
- Lesions appeared on non-irradiated skin, ranging from 3 to over 20 per patient.
Findings:
- Histopathological examination confirmed the lesions as eccrine poroma, Pinkus type.
- Intensive chemotherapy, independent of radiation, appears to be a potential cause of multiple eccrine poromas.
- The onset of eccrine poromatosis could be delayed, occurring years after chemotherapy completion.
Implications:
- Chemotherapy should be considered a risk factor for developing multiple eccrine poromas.
- Further research is needed to elucidate the mechanisms linking chemotherapy to eccrine poromatosis.
- Clinicians should be aware of this potential side effect in patients with a history of chemotherapy.
