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Related Experiment Video

Updated: May 25, 2026

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse
05:50

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Published on: February 12, 2020

Place preference test in rodents.

Sylvain Roux1, Christelle Froger, Roger D Porsolt

  • 1Porsolt and Partners Pharmacology, Boulogne Billancourt, France.

Current Protocols in Pharmacology
|February 2, 2012
PubMed
Summary
This summary is machine-generated.

Conditioned place preference testing measures drug reward by associating a compound with a specific environment. This updated protocol details its use in rats and mice, including genetically modified lines, for evaluating drug effects.

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Related Experiment Videos

Last Updated: May 25, 2026

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse
05:50

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Published on: February 12, 2020

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08:29

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Published on: June 7, 2018

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Published on: June 18, 2018

Area of Science:

  • Behavioral neuroscience
  • Pharmacology
  • Animal models

Background:

  • Conditioned place preference (CPP) is a standard behavioral paradigm.
  • It measures the rewarding properties of drugs by associating them with environmental cues.
  • Advantages include no instrumental learning and assessment of reinforcing effects without the drug present.

Purpose of the Study:

  • To update and detail procedures for conditioned place preference (CPP) testing.
  • To include protocols for both rats and mice, accommodating genetically modified lines.
  • To provide methods for evaluating drug effects using the CPP paradigm.

Main Methods:

  • Utilizes a behavioral model where environmental context is paired with drug administration.
  • Adaptable for use in both rats and mice, including various genetically modified strains.
  • Focuses on measuring the animal's preference for the environment associated with the drug.

Main Results:

  • The updated protocol facilitates CPP testing across different rodent species and genetic backgrounds.
  • Enables reliable measurement of drug-induced rewarding effects.
  • Provides a framework for evaluating the impact of specific genetic modifications on drug reward.

Conclusions:

  • The conditioned place preference test is a valuable tool for assessing drug reward.
  • The updated procedures enhance its applicability to diverse rodent models, including genetically modified mice.
  • This model is crucial for understanding the neurobiological basis of drug reinforcement.