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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...

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Related Experiment Video

Updated: May 25, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Hypothermia and Ischemic Stroke.

Rainer Kollmar1, Stefan Schwab

  • 1Department of Neurology, University of Erlangen-Nuernberg, Schwabachanlage 6, 91054, Erlangen, Germany, rainer.kollmar@uk-erlangen.de.

Current Treatment Options in Neurology
|February 2, 2012
PubMed
Summary
This summary is machine-generated.

Therapeutic hypothermia (TH) shows promise for acute ischemic stroke treatment, offering multimodal benefits. However, more large-scale clinical trials are needed to establish its efficacy and optimize its use in patients.

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In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
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In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

Related Experiment Videos

Last Updated: May 25, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
08:22

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

Area of Science:

  • Neurology
  • Emergency Medicine
  • Critical Care

Background:

  • Tissue plasminogen activator (tPA) is the primary treatment for acute ischemic stroke but has limited reach.
  • Neuroprotectants have shown limited success in translating animal data to human stroke patients.
  • Fever correlates with poor outcomes in stroke patients, suggesting a role for temperature modulation.

Purpose of the Study:

  • To evaluate the potential of therapeutic hypothermia (TH) as a treatment for acute ischemic stroke.
  • To explore TH's benefits in managing brain edema and intracranial pressure in severe stroke.
  • To identify challenges and future directions for TH implementation in clinical stroke care.

Main Methods:

  • Review of existing arguments and preliminary data supporting TH in acute brain injury.
  • Discussion of TH's multimodal effects, including its impact on fever and intracranial pressure.
  • Acknowledgement of the need for large, multicenter randomized controlled trials (RCTs) to confirm efficacy.

Main Results:

  • Current clinical data are insufficient to recommend TH for routine acute ischemic stroke treatment.
  • TH has demonstrated benefits in other acute brain injuries, such as resuscitation and perinatal asphyxia.
  • TH may help control intracranial pressure associated with brain edema in severe stroke cases.

Conclusions:

  • While promising, TH requires further investigation through high-quality RCTs to establish its role in stroke care.
  • Optimizing TH protocols, including depth, duration, and cooling methods, is crucial for successful translation.
  • Addressing challenges in awake stroke patients, such as managing cold-induced responses, is necessary for early clinical application.