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Updated: May 25, 2026
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The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
Published on: March 8, 2019
Monocrotaline-induced pulmonary hypertension in Wistar rats
Markus Rey1, Patrick Hess, Martine Clozel
1Actelion Pharmaceuticals, Allschwil, Switzerland.
Current Protocols in Pharmacology
|February 2, 2012
Abstract:
Pulmonary arterial hypertension (PAH) is a debilitating and often fatal disease characterized by a progressive increase in pulmonary vascular resistance that leads to right ventricular failure. Described in this unit is an in vivo model of monocrotaline-induced pulmonary hypertension in rats that can be used to assess the effects of antihypertensive agents on pulmonary artery pressure and right ventricular hypertrophy.
