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Drug performance sensitivity: a pilot study.

H Moskowitz1, D Chen

  • 1Southern California Research Institute, Los Angeles.

Journal of Clinical Psychopharmacology
|August 1, 1990
PubMed
Summary
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Flurazepam (Dalmane) at a high dose impaired choice reaction time, divided attention, vigilance, and addition tasks in healthy men. Subjective mood and performance measures were useful, but not the Hopkins Symptom Checklist.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Psychology

Background:

  • Flurazepam is a benzodiazepine used for insomnia.
  • High doses may affect cognitive and psychomotor functions.
  • Standardized testing is crucial for evaluating drug effects.

Purpose of the Study:

  • To evaluate the sensitivity of psychomotor and cognitive tasks to a high dose of flurazepam.
  • To assess subjective performance and mood changes.
  • To standardize testing procedures for future studies.

Main Methods:

  • Double-blind, placebo-controlled, Latin square crossover design.
  • Thirty healthy adult men received flurazepam (45 mg) or placebo at 72-hour intervals.
  • Psychomotor tests (simple/choice reaction time, divided attention, vigilance) and cognitive tasks (addition, reading comprehension) were used.

Related Experiment Videos

Main Results:

  • Choice reaction time, divided attention, and vigilance tasks were sensitive to flurazepam.
  • Addition task performance was impaired, but reading comprehension was not.
  • Subjective evaluations of performance and mood were useful, unlike Hopkins Symptom Checklist responses.

Conclusions:

  • High-dose flurazepam significantly affects specific psychomotor and cognitive functions.
  • Subjective measures can be valuable but require careful selection.
  • Standardized testing protocols enhance the reliability of drug effect evaluation.