Related Experiment Videos

Prevalence and predictors of low vitamin D concentrations in urban Canadian toddlers

Jonathon L Maguire1, Catherine S Birken, Deborah L O'Connor

  • 1Department of Pediatrics, St Michael's Hospital;

Insights

Many Canadian toddlers have low vitamin D levels, with higher body mass index (BMI) and lower cow

Area of Science:

  • Pediatric Nutrition
  • Nutritional Biochemistry
  • Public Health

Background:

  • Vitamin D is crucial for bone health and immune function in children.
  • Low vitamin D concentrations (hypovitaminosis D) are a growing concern in pediatric populations globally.
  • Urban environments and lifestyle factors may influence vitamin D status in toddlers.

Purpose of the Study:

  • To assess the prevalence of vitamin D deficiency in healthy two-year-old children in Toronto, Canada.
  • To investigate the association between body mass index (BMI) and cow's milk intake with vitamin D status.
  • To identify potential modifiable risk factors for low vitamin D in urban toddlers.

Main Methods:

  • A cross-sectional study involving 91 healthy children aged 24-30 months in Toronto, Ontario.
  • Dietary intake, including cow's milk consumption, was assessed via questionnaire.
  • Vitamin D status was determined by measuring 25-hydroxyvitamin D concentrations, with low levels defined as <50 nmol/L or <75 nmol/L.

Main Results:

  • The prevalence of low vitamin D (<50 nmol/L) was 32%, and <75 nmol/L was 82%.
  • Higher BMI was associated with an increased odds of low vitamin D (<50 nmol/L).
  • Each additional daily cup of cow's milk intake was associated with a decreased odds of low vitamin D (<50 nmol/L).

Conclusions:

  • A significant proportion of urban Canadian toddlers exhibit insufficient vitamin D levels.
  • Lower cow's milk intake and higher BMI are associated with reduced vitamin D status in this cohort.
  • The findings highlight the need for targeted interventions to improve vitamin D status in Canadian toddlers.
Abstract

Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...