Related Experiment Video

Updated: May 25, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
08:01

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Biobanking in atherosclerotic disease, opportunities and pitfalls

V P W Scholtes1, J P P M de Vries, L M Catanzariti

  • 1Experimental Laboratory Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Current Cardiology Reviews
|February 2, 2012
PubMed

Insights

Biobanks are crucial for discovering cardiovascular disease biomarkers. This review explores the benefits and challenges of using biobanks to understand atherosclerosis and identify at-risk patients.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Biobanking Research

Background:

  • Cardiovascular disease (CVD) is a leading cause of mortality in Western nations.
  • Understanding atherosclerosis pathophysiology relies on human tissue analysis.
  • Identifying patients at risk for cardiovascular complications remains a challenge.

Purpose of the Study:

  • To review the advantages and disadvantages of biobanking for cardiovascular disease research.
  • To highlight the importance of biobanks in biomarker discovery for atherosclerosis.
  • To discuss the role of biobanks in studying genetic and environmental factors in multifactorial diseases.

Main Methods:

  • Literature review focusing on atherosclerotic biobanking.
  • Analysis of existing research on cardiovascular disease pathogenesis.
  • Evaluation of biobank utility in biomarker identification and validation.

Main Results:

  • Biobanks provide essential resources for studying multifactorial diseases like atherosclerosis.
  • They facilitate the identification and validation of novel predictive cardiovascular biomarkers.
  • Well-organized biobanks enable the study of genetic and environmental influences.

Conclusions:

  • Biobanking is vital for advancing cardiovascular disease research and patient stratification.
  • Overcoming challenges in biobanking is key to unlocking its full potential.
  • Continued research using biobanks will improve therapeutic strategies for cardiovascular diseases.

Keywords:
Atherosclerosismultifactorial diseasenovel biomarkerspathophysiology.

More Related Videos

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...