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Related Experiment Videos

Problems of resistant dermatophytes.

H E Jones1

  • 1Emory University, Atlanta, Ga.

Journal of the American Academy of Dermatology
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

Recalcitrant fungal infections are hard to treat due to various factors beyond just drug resistance. Optimizing antifungal drug delivery to the stratum corneum by enhancing sweating may improve treatment outcomes.

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Area of Science:

  • Dermatology
  • Mycology
  • Pharmacology

Background:

  • Recalcitrant fungal infections are challenging to eradicate despite appropriate antibiotic treatment.
  • Microbial resistance is one cause, but patient compliance, drug metabolism, and drug delivery also contribute.
  • Current oral antifungal agents like griseofulvin and ketoconazole rely on eccrine sweat for stratum corneum delivery.

Purpose of the Study:

  • To explore the multifaceted causes of recalcitrant fungal infections.
  • To identify key factors influencing the efficacy of oral antifungal agents.
  • To propose strategies for optimizing antifungal drug delivery to the stratum corneum.

Main Methods:

  • Review of existing literature on fungal infections and antifungal pharmacokinetics.

Related Experiment Videos

  • Analysis of drug delivery pathways to the stratum corneum.
  • Identification of factors affecting drug concentration at the site of infection.

    • Main Results:

    • Recalcitrant infections stem from diverse issues including non-compliance, drug degradation, and poor drug penetration.
    • Eccrine sweat excretion is the primary route for griseofulvin and ketoconazole to reach the stratum corneum.
    • Drug washout and absorption by clothing can reduce efficacy.

    Conclusions:

    • Optimizing antifungal therapy requires addressing factors beyond microbial resistance.
    • Enhancing sweating can improve the delivery of oral antifungals to the stratum corneum.
    • Minimizing drug loss through runoff and clothing absorption is crucial for therapeutic success.