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Related Experiment Videos

Severe lidocaine intoxication by cutaneous absorption.

R L Lie1, B J Vermeer, P M Edelbroek

  • 1Department of Internal Medicine, University Hospital Leiden, The Netherlands.

Journal of the American Academy of Dermatology
|November 1, 1990
PubMed
Summary
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Severe lidocaine intoxication can occur through skin absorption, especially with diseased skin. This route is crucial for clinicians to consider when patients use large amounts of lidocaine cream.

Area of Science:

  • Pharmacology
  • Dermatology
  • Toxicology

Background:

  • Lidocaine is a common local anesthetic used topically.
  • Cutaneous absorption of topical medications can vary based on skin integrity.

Observation:

  • A case of severe lidocaine intoxication was observed.
  • The intoxication was attributed to cutaneous absorption via topical application.

Findings:

  • Significant lidocaine absorption occurs through diseased skin.
  • Lidocaine cream, when applied to compromised skin, leads to substantial systemic uptake.

Implications:

  • Clinicians must be aware of significant lidocaine absorption through diseased skin.
  • Monitoring for systemic toxicity is essential in patients using large quantities of lidocaine cream, particularly with compromised skin.

Related Experiment Videos

  • Neurologic and psychiatric symptoms in patients using lidocaine cream may indicate systemic toxicity.