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Updated: May 25, 2026
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Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
[Study on the haemostatic efficiency of composite bio-particles]
Donghong Li1, Hua Gao, Jiatao Zang
1State Key Laboratory of Trauma, Burn and Combined Injury, the 2nd Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China. lqs_cq@yahoo.com.cn
Summary
A novel composite particle (CP) and tranexamic acid-loaded composite particle (TACP) were developed. TACP demonstrated superior hemostatic efficiency compared to CP and a commercial control in rabbit hemorrhage models.
Area of Science:
- Biomaterials Science
- Hemostasis Research
- Composite Particle Technology
Context:
- Hemorrhage control remains a critical challenge in emergency medicine and surgery.
- Developing effective and safe hemostatic agents is an ongoing area of research.
- Existing hemostatic agents have limitations in efficacy or application.
Purpose:
- To fabricate and evaluate a novel porous composite particle (CP) based on chitosan, alginate, and collagen protein.
- To prepare tranexamic acid-loaded composite particles (TACP) for enhanced hemostatic properties.
- To compare the hemostatic efficacy of CP and TACP against a commercial control (Flashclot) in rabbit hemorrhage models.
Summary:
- Porous composite particles (CP) were successfully fabricated using chitosan, alginate, and collagen protein via emulsification and cross-linking.
- Tranexamic acid-loaded composite particles (TACP) were prepared by immersing CP in tranexamic acid solution followed by freeze-drying.
- In rabbit hepatic and splenic hemorrhage models, TACP exhibited significantly shorter hemostatic times (1.90 ± 0.75 min) compared to CP (2.48 ± 0.88 min) and Flashclot (3.07 ± 0.84 min) (P < 0.05).
Impact:
- The fabricated CP demonstrated comparable hemostatic efficiency to the commercial product Flashclot.
- TACP showed superior hemostatic performance, indicating its potential as a promising hemostatic powder.
- This research contributes to the development of advanced biomaterials for effective bleeding management.
