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Updated: May 25, 2026

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

Sequestosome 1/p62: across diseases.

Thangiah Geetha¹, Nilmini Vishwaprakash, Marina Sycheva

¹Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, USA.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

|February 3, 2012

Summary

Sequestosome 1/p62, a key signaling protein, is increasingly recognized for its role in various diseases like neurodegeneration and cancer. This review highlights recent advances in understanding its physiological functions related to human pathologies.

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Last Updated: May 25, 2026

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

Area of Science:

Molecular Biology
Cell Signaling
Pathophysiology

Background:

Sequestosome 1 (p62) acts as a crucial signal modulator and adaptor protein in receptor-mediated signal transduction pathways.
Dysregulation of p62 function is implicated in the pathogenesis of numerous human diseases, including neurodegenerative disorders and various cancers.
The protein's involvement spans conditions such as Parkinson disease, Alzheimer disease, liver and breast cancer, Paget's disease of bone, obesity, and insulin resistance.

Purpose of the Study:

To review the most recent scientific advances concerning the physiological functions of Sequestosome 1/p62.
To elucidate the specific roles of p62 in the context of various human diseases.
To provide an updated perspective on p62 as a potential therapeutic target.

Main Methods:

Literature review of recent research publications.
Analysis of studies focusing on the molecular and cellular functions of p62.
Synthesis of findings related to p62's involvement in disease mechanisms.

Main Results:

Recent studies have uncovered novel signaling pathways regulated by p62.
Advances highlight p62's critical role in cellular processes such as autophagy, inflammation, and cell survival.
Specific molecular mechanisms linking p62 to disease progression in neurological disorders and cancer have been elucidated.

Conclusions:

Sequestosome 1/p62 is a pivotal protein with diverse physiological roles directly relevant to human health and disease.
Understanding p62's complex functions offers potential for developing novel therapeutic strategies for a range of debilitating conditions.
Further research into p62 signaling is essential for advancing treatments for diseases like Alzheimer's, Parkinson's, and cancer.