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Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
Published on: September 14, 2018
Programmable self-assembly of antibody-oligonucleotide conjugates as small molecule and protein carriers
Amit Gangar1, Adrian Fegan, Sidath C Kumarapperuma
1Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Journal of the American Chemical Society
|February 3, 2012
Abstract:
Dihydrofolate reductase single-chain variable fragment (scFv) fusion proteins can be used for the targeted cellular delivery of oligonucleotides, conjugated small molecules, and proteins via labeling of oligonucleotides by bis-methotrexate.
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