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Related Experiment Video

Updated: May 25, 2026

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Oxidative stress in pathological pregnancies.

G Clerici1, C Slavescu, S Fiengo

  • 1Centre of Reproductive and Perinatal Medicine, Department of Gynecology and Obstetrics, University of Perugia, Perugia, Italy.

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
|February 3, 2012
PubMed
Summary

Oxidative stress (OS) is elevated in high-risk pregnancies. Reduced antioxidant and thiolyte capacities, alongside increased pro-oxidant capacity, were observed in women with pre-eclampsia, diabetes, and preterm labor.

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Published on: December 11, 2020

Area of Science:

  • Obstetrics and Gynecology
  • Biochemistry
  • Perinatal Medicine

Background:

  • Oxidative stress (OS) is implicated in pregnancy complications such as pre-eclampsia, gestational diabetes, and preterm labor.
  • Understanding OS markers is crucial for managing at-risk pregnancies.

Purpose of the Study:

  • To investigate the role of oxidative stress in pathological pregnancies.
  • To compare markers of oxidative stress in normal pregnancies versus those with pre-eclampsia, gestational diabetes, or preterm labor.

Main Methods:

  • Measured three oxidative stress markers: total antioxidant capacity (TAC), thiolyte capacity, and pro-oxidant capacity.
  • Analyzed plasma samples from 45 women: 15 in normal pregnancies, 17 in pathological pregnancies (pre-eclampsia, pregestational diabetes), and 13 with preterm labor.

Main Results:

  • Significantly reduced plasma TAC and thiolyte capacity were found in pathological pregnancies and preterm labor groups compared to controls.
  • Significantly higher pro-oxidant capacity was observed in pathological pregnancies and preterm labor groups versus controls.
  • Elevated OS markers were evident in women with pregnancy complications.

Conclusions:

  • Oxidative stress plays a significant role in adverse pregnancy outcomes.
  • OS markers can help identify and potentially manage conditions like pre-eclampsia, diabetes, and preterm birth.