Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
Pedigree Analysis01:35

Pedigree Analysis

Overview
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Minerals01:26

Minerals

Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gender-affirming care in South Africa: A cross-sectional survey of transgender and gender-diverse people in the Eastern and Western Cape provinces, South Africa.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
Same author

Parenteral artesunate compliance and hospital outcomes in children under five with suspected severe malaria in Sierra Leone.

Public health action·2026
Same author

SIGNIFIED: whole-body MRI screening in Li-Fraumeni syndrome in the UK.

ESMO open·2026
Same author

Extension of the intravitreal injection interval after switching to faricimab in patients with exudative AMD: The multicenter FAR WEST study.

Journal francais d'ophtalmologie·2026
Same author

Li Fraumeni syndrome in the UK: clinical characteristics and outcomes of TP53 carriers.

ESMO open·2025
Same author

The Absence of Claudin-10 in the Enamel Organ Alters Its Integrity.

Journal of dental research·2025

Related Experiment Video

Updated: May 25, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
08:12

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

Tooth dentin defects reflect genetic disorders affecting bone mineralization.

S Opsahl Vital1, C Gaucher, C Bardet

  • 1Dental School University Paris Descartes PRES Sorbonne Paris Cité, EA 2496, Montrouge, F-92120, France.

Bone
|February 3, 2012
PubMed
Summary
This summary is machine-generated.

Dentin, a mineralized tissue, serves as a valuable model for studying genetic bone disorders like rickets and osteogenesis imperfecta. Examining dentin offers insights into biomineralization processes and treatment effects.

More Related Videos

Accessing the Cytotoxicity and Cell Response to Biomaterials
09:46

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models
06:16

Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models

Published on: April 26, 2024

Related Experiment Videos

Last Updated: May 25, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
08:12

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

Accessing the Cytotoxicity and Cell Response to Biomaterials
09:46

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models
06:16

Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models

Published on: April 26, 2024

Area of Science:

  • Biomineralization research
  • Dental and bone biology
  • Genetic disorder pathology

Background:

  • Dentin and bone share extracellular matrix (ECM) similarities, with both mineralized tissues affected by genetic disorders.
  • Unlike bone, dentin is not remodeled and not involved in calcium/phosphate metabolism, but teeth offer accessible samples.
  • Genetic disorders disrupt dentin and bone mineralization, impacting ECM organization and potentially systemic metabolism.

Purpose of the Study:

  • To review genetic disorders affecting both bone and dentin mineralization.
  • To highlight dentin as a model for studying biomineralization.
  • To discuss the role of dentin in evaluating treatment efficacy for genetic conditions.

Main Methods:

  • Review of literature on genetic disorders impacting bone and dentin mineralization.
  • Comparative analysis of dentin and bone ECM.
  • Case examples of Hypophosphatemic rickets and Osteogenesis imperfecta.

Main Results:

  • Genetic disorders like Hypophosphatemic rickets and Osteogenesis imperfecta disrupt dentin and bone mineralization.
  • Dentin's accessibility allows for monitoring disease progression and treatment effects.
  • Abnormalities in ECM organization and potential metabolic dysregulation are key findings.

Conclusions:

  • Dentin is a valuable and accessible model for studying biomineralization in genetic disorders.
  • Examination of dentin aids in understanding pathological processes and evaluating systemic treatments.
  • Further research into dentin biomineralization can improve management of related genetic diseases.