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A benzothiazole alkyne fluorescent sensor for Cu detection in living cell
Jianjun Qi1, Myung Shin Han, Ching-Hsuan Tung
1Department of Radiology, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA.
Bioorganic & Medicinal Chemistry Letters
|February 3, 2012
Abstract
None:
A new type of alkyne dye, 6-dimethylaminobenzothiazole alkyne (1), was developed for Cu sensing in biological system. Dye (1) offered excellent selective over a panel of ions, only Cu(I) could change the fluorescence of dye (I) by forming copper acetylide between the terminal alkyne and Cu(I). Its potential of detecting Cu in biological system was demonstrated in cell culture.
