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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Diffusion tensor imaging: tract based spatial statistics study in essential tremor.

Jitender Saini1, Bhavani Shankara Bagepally, Maya Dattatraya Bhatt

  • 1Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore-560029, Karnataka, India.

Parkinsonism & Related Disorders
|February 3, 2012
PubMed
Summary
This summary is machine-generated.

Essential tremor (ET) involves white matter damage in the brain, particularly in the cerebral and cerebellar regions. Diffusion Tensor Imaging (DTI) revealed axonal disintegration, indicating neurodegeneration in patients with ET.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Biomedical Engineering

Background:

  • Essential tremor (ET) is a prevalent movement disorder characterized by both motor and non-motor symptoms.
  • Understanding the underlying neurodegenerative processes in ET is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate neurodegenerative changes in the brain white matter of Essential Tremor (ET) patients.
  • Utilize Diffusion Tensor Imaging (DTI) to assess white matter integrity in ET.

Main Methods:

  • Prospective collection of clinical and MRI data from 20 ET patients and 17 controls.
  • Tract-Based Spatial Statistics (TBSS) and Region of Interest (ROI) analysis of DTI data.
  • Examination of white matter integrity in specific brain regions like the corpus callosum, internal capsule, and cerebellar peduncles.

Main Results:

  • ET patients exhibited increased mean and radial diffusivity in the right frontoparietal white matter compared to controls.
  • Elevated axial diffusivity was observed in bilateral cerebral hemispheres, thalamus, brainstem, and cerebellar white matter.
  • Region of interest analysis identified abnormalities in the anterior limb of the internal capsule and cerebellar peduncles, with no significant changes in fractional anisotropy.

Conclusions:

  • The study provides in vivo evidence of axonal disintegration in the cerebral and cerebellar white matter of ET patients.
  • These findings suggest widespread white matter damage contributing to the pathophysiology of Essential Tremor.