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Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing

Adham S Bear1, Richard A Morgan, Kenneth Cornetta

  • 1Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and The Methodist Hospital, Houston, Texas 77030, USA.

Molecular Therapy : the Journal of the American Society of Gene Therapy
|February 3, 2012
PubMed
Abstract

No abstract available in PubMed .

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...