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Related Concept Videos

Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
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Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Related Experiment Video

Updated: May 25, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

[Candida infections in the elderly].

H Hof1, G Mikus

  • 1Labor Limbach, Heidelberg. herbert-hof@labor-limbach.de

Zeitschrift Fur Gerontologie Und Geriatrie
|February 3, 2012
PubMed
Summary
This summary is machine-generated.

Candida infections are more severe in the elderly due to immune system changes. Echinocandins are recommended for treating these yeast infections, especially Candida glabrata, due to their safety and efficacy.

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Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Area of Science:

  • Mycology
  • Immunology
  • Geriatrics

Context:

  • Elderly individuals experience more frequent and severe Candida infections affecting skin, mucous membranes, and internal organs.
  • Age-related immune system alterations contribute to increased susceptibility and severity of fungal infections.
  • Candida glabrata is an emerging pathogen associated with higher mortality and reduced susceptibility to fluconazole.

Purpose:

  • To highlight the challenges in treating Candida infections in the elderly.
  • To discuss the changing landscape of Candida pathogens, including the rise of Candida glabrata.
  • To evaluate antifungal treatment options, focusing on echinocandins for elderly patients.

Summary:

  • Candida albicans is the primary pathogen, but Candida glabrata infections are increasing in the elderly population.
  • Candida glabrata exhibits reduced susceptibility to fluconazole, necessitating alternative treatment strategies.
  • Echinocandins are effective against yeasts, possess low toxicity, and have minimal drug interaction potential, making them suitable for the elderly.

Impact:

  • Informing clinical decisions for antifungal therapy in geriatric populations.
  • Guiding the selection of appropriate treatments to improve outcomes for elderly patients with invasive fungal infections.
  • Emphasizing the importance of considering pathogen-specific resistance patterns and patient comorbidities in antifungal drug selection.