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Updated: May 25, 2026
07:13
Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
Published on: October 27, 2023
Imaging: strategies, controversies, and opportunities
Ronald Blasberg1, David Piwnica-Worms
1Department of Neurology, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. blasberg@neuro1.mskcc.org
Summary
New molecular imaging techniques are revolutionizing cancer research by focusing on disease's molecular basis. These tools offer in vivo biomarkers and improve clinical trial patient selection for personalized cancer care.
Area of Science:
- Oncology
- Medical Imaging
- Translational Research
Background:
- Discussions at a 2010 cancer research think tank highlighted emerging imaging technologies.
- Focus shifted from established techniques to future opportunities in translational imaging.
Purpose of the Study:
- To explore how new imaging methods are transforming cancer research from anatomical to molecular focus.
- To discuss the potential of molecular imaging in advancing cancer diagnosis and treatment.
Main Methods:
- Incorporation of cell and molecular biology into image generation.
- Development of strategies to image gene expression products in vivo.
- Utilizing external imaging devices for molecular imaging.
Main Results:
- New methods promise robust linkages between preclinical models and clinical trials.
- Enabling in vivo biomarkers for dynamic disease monitoring and treatment response assessment.
- Providing tools for patient stratification in clinical trials to enhance outcomes.
Conclusions:
- Molecular imaging offers real-time pharmacodynamic parameters for monitoring therapeutic effects.
- These strategies can accelerate drug development and reduce costs.
- Imaging techniques, like the Imaging Response Assessment Team (IRAT) program, are crucial for individualized patient care and clinical trial success.
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