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Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
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Carotid intima media thickness and cardiometabolic risk associates in Turkish adults

Fahri Halit Besir1, Omer Yazgan, Hakan Ozhan

  • 1Department of Radiology, Medical Faculty, Düzce University, Düzce, Turkey.

Acta Cardiologica
|February 4, 2012
PubMed

Insights

Carotid intima media thickness (CIMT) is a predictor of vascular events. In Turkish adults, age, systolic blood pressure, and smoking are key associates of CIMT, with hypertension also being an independent predictor.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Public Health

Background:

  • Carotid intima media thickness (CIMT) is a validated marker for predicting future vascular events.
  • Limited data exists on CIMT and its associated risk factors within the Turkish population.
  • Understanding these associations is crucial for cardiovascular risk stratification.

Purpose of the Study:

  • To investigate carotid intima media thickness (CIMT) in a large cohort of Turkish adults.
  • To identify cardiometabolic risk factors associated with CIMT in this population.
  • To establish predictors of thickened CIMT for improved cardiovascular risk assessment.

Main Methods:

  • A cohort of 2230 Turkish adults (1427 women, 803 men; mean age 49) underwent Doppler Ultrasound for CIMT measurement.
  • Statistical analyses included age- and sex-adjusted partial correlation and Receiver Operator Characteristics (ROC) analysis.
  • Logistic regression identified independent predictors of thickened CIMT (>0.8 mm).

Main Results:

  • Mean CIMT was 0.61 ± 0.19 mm.
  • Age and smoking amount were significantly correlated with CIMT after adjustment.
  • Hypertension (OR=2.74), systolic blood pressure (OR=1.01), and age (OR=1.11) were independent predictors of high CIMT.

Conclusions:

  • Age, systolic blood pressure, and smoking amount are the primary associates of CIMT in Turkish adults.
  • Age demonstrated the highest Area Under the Curve (AUC) in ROC analysis for predicting thickened CIMT.
  • Hypertension, elevated systolic blood pressure, and advanced age are significant independent predictors of increased CIMT in this population.
Abstract

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