Related Experiment Video
Updated: May 25, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Three new aromatic sulfonamide inhibitors of carbonic anhydrases I, II, IV and XII
C T Supuran1, A Maresca, F Gregáň
1Dipartimento di Chimica, Università di Firenze, Via della Lastruccia, Sesto Fiorentino (Firenze), Italy.
Abstract:
4-Sulfamoyl-N-(3-morpholinopropyl)benzamide (I-1), N-(3-morpholinopropyl)benzene-1,4-disulfonamide (I-2) and N-(4-diethylaminoethoxybenzyl)benzene-1,4-bis(sulfonamide (I-3), were prepared and assayed as inhibitors of four carbonic anhydrase (CA) isoenzymes hCA I, hCA II, hCA IV and hCA XII. These compounds exhibited nanomolar half maximal inhibitory concentration (IC(50)) ranging from 58 to 740 nmol/L. All three aromatic sulfonamides show different activities for the isoenzymes studied with lowest affinity against isoenzyme hCA XII.
Related Concept Videos
Antihypertensive Drugs: Thiazide-Class Diuretics
Amines to Sulfonamides: The Hinsberg Test
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing sulfonyl...
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Electrophilic Aromatic Substitution: Sulfonation of Benzene
