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A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Mandibular distraction in neonates: indications, technique, results
Enrico Sesenna1, Alice S Magri, Cinzia Magnani
1Maxillo-Facial Surgery Division, Head and Neck Department, University and Hospital of Parma, Parma, Italy.
Italian Journal of Pediatrics
|February 4, 2012
Summary
Mandibular Distraction Osteogenesis effectively resolves respiratory distress in infants with severe micrognathia when other treatments fail. This procedure improved airway obstruction and feeding, successfully removing tracheotomies in all cases.
Area of Science:
- Craniofacial Surgery
- Pediatric Otolaryngology
- Maxillofacial Surgery
Background:
- Pierre Robin Sequence (PRS) affects 1:8,500–20,000 newborns, characterized by micrognathia, glossoptosis, and respiratory distress.
- Upper airway obstruction and feeding difficulties are primary concerns in PRS patients.
- Mandibular Distraction Osteogenesis (MDO) is a viable treatment option for severe cases unresponsive to other interventions.
Purpose of the Study:
- To evaluate the efficacy of Mandibular Distraction Osteogenesis (MDO) in treating severe micrognathia and airway obstruction in pediatric patients.
- To assess the impact of MDO on respiratory distress, feeding, and the need for tracheotomy.
Main Methods:
- Ten pediatric patients (1 month–2 years) with severe micrognathia and airway obstruction underwent MDO.
- Diagnostic methods included airway fibroscopy and imaging (radiography/CT) to confirm posterior tongue displacement.
- Surgical approaches involved bilateral mandibular distraction using external or internal devices; two patients had pre-existing tracheotomies.
Main Results:
- All patients experienced symptom resolution, with successful tracheotomy removal in those who had them.
- One patient with Goldenhar Syndrome required a Montgomery device for 6 months post-surgery due to tracheomalacia.
- Improved airway patency, maxillomandibular relationship, and feeding were observed; no inferior alveolar nerve injury noted.
Conclusions:
- Mandibular Distraction Osteogenesis is a highly effective solution for pediatric respiratory distress secondary to severe micrognathia.
- MDO offers significant benefits when conventional treatments are inadequate, improving both airway and feeding functions.
- The procedure demonstrates a favorable safety profile with minimal long-term complications such as scarring or nerve damage.
